Treat the system, not the symptoms.
Trueform facilitates access to a wide range of medical treatments and supplements for functional health optimisation.
Get started nowTrueform facilitates access to a wide range of medical treatments and supplements for functional health optimisation.
Get started nowThe information on this page is intended for educational purposes only and should not be considered medical advice or a substitute for professional medical consultation.
Some of the treatments on this page represent an evolving area of medicine. Most therapies are supported by established clinical evidence, although some are based on promising preclinical and early human research. For these, large-scale human clinical trials are still ongoing to fully establish long-term safety, efficacy, and therapeutic use. All medications are manufactured in SAPC-licensed and regulated facilities following GMP principles to ensure the highest possible quality products.
Your doctor will evaluate your medical history, current health, and individual goals before recommending any treatment. Nothing is prescribed without a thorough clinical assessment to ensure treatment is appropriate.
Treatments
BPC-157 (Body Protection Compound 157) is a 15-amino acid peptide that has gained significant attention in regenerative medicine and injury recovery. Originally derived from a protein found in gastric juice, it works through multiple biological pathways, making it one of the more versatile peptides currently used in a therapeutic setting.
Preclinical studies suggest BPC-157 may promote angiogenesis (formation of new blood vessels), support tissue repair, and influence inflammatory pathways. It has also been observed to affect nitric oxide signalling, which plays a role in blood flow and cellular communication.
BPC-157 also promotes nitric oxide synthesis, which may improve blood flow, support immune function, and enhance neurotransmission. Research suggests it stimulates the production of growth factors essential for tissue maintenance and repair at the cellular level.
Emerging research points to neurological and digestive applications. BPC-157 appears to influence the gut-brain axis - the communication network between the gastrointestinal tract and central nervous system - with neuroprotective effects and cognitive improvements observed in animal studies. Its interaction with dopaminergic and serotonergic systems suggests broader potential in mood regulation and cognitive health, though these applications require further clinical validation.
TB-500 is a synthetic 42-amino acid peptide derived from Thymosin Beta-4, a naturally occurring protein first identified in 1981. It has become a focus of regenerative medicine research for its ability to promote systemic healing and tissue repair.
TB-500 facilitates cell migration to injury sites and promotes angiogenesis, ensuring damaged tissues receive adequate blood supply. It also reduces excessive scar tissue formation and modulates the inflammatory response, leading to higher-quality tissue repair. These properties are particularly relevant for connective tissues such as tendons and ligaments, where proper cell movement and tissue reorganisation are critical for recovery.
The peptide shows promise in cardiovascular health as research suggests it may help protect and repair cardiac muscle following ischaemic damage by supporting cell survival and promoting new blood vessel growth. For skeletal muscle, TB-500 aids fibre regeneration by supporting muscle cell proliferation and differentiation. Animal studies have also indicated potential benefits for insulin sensitivity and glucose regulation.
Ipamorelin is a synthetic five-amino acid peptide that stimulates the body's natural growth hormone production by mimicking ghrelin, the hormone that signals the pituitary gland to release growth hormone. What distinguishes ipamorelin from other growth hormone-releasing peptides is its selectivity: it promotes growth hormone release without activating the body's stress response.
By binding to ghrelin receptors, ipamorelin triggers increased growth hormone levels, which influence body composition, tissue health, and metabolic function. Clinical studies have demonstrated its ability to protect against muscle breakdown and support bone mineral density. The peptide may also stimulate smooth muscle in the digestive system, potentially improving gastric motility.
Due to its similarity to ghrelin, ipamorelin is believed to support angiogenesis and collagen synthesis — processes important for cartilage, joint, and skin repair. Elevated growth hormone levels support the body's natural regenerative capacity, including tissue healing and maintenance of connective tissue integrity.
Semax is a synthetic peptide developed from a fragment of adrenocorticotropic hormone (ACTH). Its molecular structure allows it to cross the blood-brain barrier and reach significant concentrations in the central nervous system. It is authorised in Eastern Europe for the treatment of stroke, cognitive disorders, and dementia.
Semax stimulates the production of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) — proteins essential for brain cell survival, growth, and neuroplasticity. Clinical studies have demonstrated improvements in memory accuracy and changes in the brain's default mode network, suggesting enhanced information processing. By also influencing serotonin, dopamine, and enkephalin signalling, Semax may support focus, learning, and overall cognitive function.
Clinical trials in stroke patients have reported improved motor performance and functional independence following Semax administration. Its anti-inflammatory effects may benefit conditions involving chronic neuroinflammation, and preclinical research suggests protective effects against neurotoxins associated with Parkinson's disease. Animal studies have also indicated anxiolytic and antidepressant properties under stress, pointing to broader applications in psychological resilience.
Selank is a synthetic peptide developed in the early 1990s at the Russian Academy of Sciences, designed as an analogue of tuftsin, which is a naturally occurring immune-regulatory peptide. It is classified as a nootropic and is recognised for its ability to reduce anxiety while enhancing cognitive function, without the sedation or dependency risks associated with benzodiazepines.
Selank modulates multiple neurotransmitter systems such as serotonin and dopamine which are central to mood regulation, mental clarity, and focus. By altering GABA receptor expression, it produces calming effects comparable to benzodiazepines but without cognitive impairment or withdrawal risk. Studies have demonstrated improvements in learning, memory, and problem-solving, particularly in models with baseline cognitive challenges.
Clinical trials show that Selank moderates the release of stress-related hormones and supports stress adaptation, making it relevant for chronic stress management. Research has also revealed immune-modulating properties — Selank influences gene expression and cytokine balance, with studies demonstrating antiviral activity against certain influenza strains. This positions it as a peptide with applications that extend well beyond cognitive enhancement.
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in every cell, functioning as both an energy currency and a master regulator of cellular health. It is essential for ATP production, DNA repair, gene expression, circadian rhythm regulation, and cell survival. NAD+ levels decline by up to 50% by middle age — a depletion now considered a fundamental driver of the ageing process.
NAD+ plays an indispensable role in mitochondrial function, driving the electron transport chain that generates cellular energy. When levels drop, mitochondrial efficiency deteriorates — leading to fatigue, insulin resistance, metabolic dysfunction, and accelerated ageing. Restoring NAD+ supports the efficient conversion of nutrients into usable energy and sustains overall physical performance and vitality.
Beyond energy production, NAD+ regulates the cellular repair and longevity pathways that preserve stem cell function, maintain tissue integrity, and may slow biological ageing at the cellular level.
NAD+ maintains the structural integrity of nerve fibres, promotes neurogenesis, and activates protective pathways in neurons. It buffers against excitotoxicity and neuroinflammation — processes that damage brain cells — and helps counter age-related cognitive decline. Research in models of Alzheimer's, Parkinson's, and stroke has demonstrated neuroprotective effects from NAD+ restoration.
MOTS-c is a mitochondrial-derived peptide discovered in 2015, encoded within the mitochondrial genome. As a "mitokine", which is a signalling molecule produced by mitochondria that circulates systemically, it is unique in its ability to communicate between mitochondria and the cell nucleus, modulating gene expression in response to metabolic stress. MOTS-c levels decline naturally with age.
MOTS-c enhances glucose uptake and insulin sensitivity, supporting efficient energy processing and metabolic function. It promotes mitochondrial biogenesis and reduces oxidative stress. Research has demonstrated effectiveness in preventing obesity and insulin resistance, particularly in postmenopausal women.
Studies show that MOTS-c supplementation can mitigate age-related physical decline and improve exercise capacity. The peptide enhances muscle performance through AMPK activation in skeletal muscle and influences genes related to angiogenesis, inflammation control, and cell survival. When combined with exercise, MOTS-c amplifies benefits by improving mitochondrial function and energy metabolism.
Research indicates MOTS-c may prevent age-related vascular stiffening. This cardiovascular protection, combined with its metabolic and mitochondrial benefits, positions it as a multifaceted intervention for healthy ageing — though comprehensive human clinical trials are still needed to establish optimal dosing and long-term safety.
GHK-Cu is a naturally occurring tripeptide discovered in 1973, found in human blood plasma, saliva, and urine. It plays a central role in the body's healing and regenerative processes, though levels decline with age. GHK-Cu functions by binding to copper, a mineral essential for enzymatic processes, and influences how cells produce and remodel structural proteins including collagen.
The peptide regulates the production of collagen and glycosaminoglycans for structural support and hydration to tissues. It attracts immune cells and endothelial cells to injury sites, supporting the body's natural healing cascade. Clinical trials have demonstrated improvements in skin quality, wound healing, and hair growth. Its antioxidant properties provide additional cellular protection against oxidative damage.
GHK-Cu influences gene expression related to tissue repair, angiogenesis (creation of new blood vessels), and nerve development. Research has shown protective and regenerative effects on liver tissue, and animal studies have even suggested potential benefits for reducing anxiety, which indicates applications that may extend beyond its established role in skin and tissue health.
Minoxidil and finasteride are two of the most extensively studied and approved treatments for androgenetic alopecia (pattern hair loss). Each addresses hair loss through a distinct mechanism, and combining both in a single formulation offers a dual-action approach.
Finasteride targets the hormonal driver of pattern hair loss by inhibiting 5-alpha reductase which is the enzyme that converts testosterone to dihydrotestosterone (DHT). DHT is directly responsible for follicle miniaturisation. Finasteride reduces DHT levels by approximately 60–70%, slowing and in many cases halting further hair loss. Minoxidil works independently of the hormonal pathway by stimulating hair follicle activity and promoting blood flow to the scalp, supporting the growth phase of the hair cycle.
Research indicates that combination therapy may produce superior outcomes in hair density and regrowth compared to either medication used alone. Individual response varies, with visible results typically appearing after 3–6 months of consistent use.
Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor primarily prescribed for erectile dysfunction. Originally marketed as Cialis, it is distinguished from similar medications by its extended half-life of up to 36 hours. This offers a significantly longer window of efficacy compared to shorter-acting alternatives such as Viagra.
Tadalafil enhances erectile function by supporting the nitric oxide pathway. During sexual stimulation, the body releases nitric oxide, which relaxes smooth muscle in penile vasculature and enables increased blood flow. Tadalafil sustains this process by preventing the premature breakdown of cyclic GMP. Its vascular benefits extend beyond erectile function since the medication promotes improved circulation systemically, with potential positive effects on cardiovascular health.
Two approaches offer flexibility based on individual needs. The 20mg as-needed protocol is taken 30–60 minutes before anticipated sexual activity, with effects lasting up to 36 hours. The 5mg daily protocol maintains continuous therapeutic levels, eliminating the need to plan ahead and allowing for spontaneity. Daily dosing may also provide relief from lower urinary tract symptoms associated with benign prostatic enlargement.
Oxytocin is a neuropeptide synthesised in the hypothalamus that functions as both a hormone and neurotransmitter. Beyond its established roles in childbirth and lactation, oxytocin has emerged as a key regulator of social behaviour, emotional processing, stress response, and multiple aspects of physical health.
Oxytocin modulates activity in the amygdala and prefrontal cortex, which are brain regions critical for emotional processing and social cognition. Thus enhancing empathy, trust, and the quality of interpersonal connection. Its anxiolytic effects arise from downregulating the HPA axis, reducing cortisol secretion, and activating the parasympathetic nervous system. This dual action mitigates stress responses and promotes feelings of safety and calm. Research also suggests benefits for self-esteem and performance anxiety.
Oxytocin produces analgesic effects by interacting with opioid and serotonin pathways. It supports neuroplasticity and memory through synaptic regulation in the hippocampus. Cardiovascular benefits include vasodilation and blood pressure reduction via nitric oxide release from endothelial cells. The peptide also influences gastrointestinal motility and inflammation through the enteric nervous system.
Oxytocin influences energy homeostasis and appetite control, with emerging implications for metabolic health. In reproductive contexts, it enhances sexual arousal, facilitates sperm transport, and strengthens pair bonding.
Testosterone is a vital hormone for both men and women. When levels fall below the normal physiological range, the effects are systemic including, but not limited to, reduced libido, chronic fatigue, mood changes, erectile dysfunction, decreased muscle mass and bone density, and diminished overall wellbeing. While testosterone naturally declines with age, deficiency is increasingly recognised in younger men and can be driven by obesity, metabolic disease, chronic illness, certain medications, and physical trauma.
TRT aims to restore testosterone to the normal physiological range, alleviating symptoms and mitigating the long-term health consequences of deficiency. It is commonly taken once or twice a week via self-administered injections of testosterone cypionate. Cypionate has a half-life of approximately 8 days which allows for precise titration and fine-grained management of free testosterone levels based on treatment response.
When properly managed, TRT can significantly improve quality of life. Benefits include restored libido and sexual function, improved mood and motivation, increased muscle mass and strength, supported bone density, increased energy levels, and correction of testosterone-related anaemia. Many patients report a meaningful return of overall vitality once hormonal balance is re-established.
TRT requires structured monitoring and is not appropriate for everyone. Regular assessment of testosterone levels, haematocrit, haemoglobin, prostate health, liver function, and cardiovascular risk factors is essential. TRT is contraindicated in individuals with hormone-sensitive cancers, elevated haematocrit, chronic heart failure, or untreated obstructive sleep apnoea. Men planning to conceive within 6–12 months should avoid TRT as it suppresses natural testosterone production and can reduce sperm count.
Testosterone replacement therapy often includes human chorionic gonadotropin (hCG) — a hormone that mimics luteinising hormone to signal the testes to maintain natural testosterone production. hCG is particularly valuable for men on TRT who wish to preserve fertility, prevent testicular atrophy, or maintain endogenous production alongside exogenous supplementation.
DHEA (dehydroepiandrosterone) is the most abundant circulating steroid hormone in the human body, produced primarily by the adrenal glands with smaller amounts synthesised in the brain and gonads. It functions as a precursor to both testosterone and oestrogen, converting into these sex hormones as the body requires. DHEA levels peak in the mid-20s and decline by approximately 80% by age 70–80.
DHEA supplementation may support healthy sex hormone levels, particularly in individuals experiencing age-related decline or adrenal insufficiency. Research suggests potential benefits including improved bone density, enhanced muscle mass, reduced body fat, and increased energy. Some studies indicate improvements in mood, cognitive function, and overall wellbeing. The hormone may also support immune function and help modulate inflammatory responses.
Supplementation has been associated with improvements in libido and sexual function, particularly in women with low DHEA levels and in older adults. Some research suggests metabolic benefits including improved insulin sensitivity and favourable effects on cardiovascular risk markers, though evidence remains mixed. DHEA may also support adrenal function and the body's capacity to adapt to stress.
Because DHEA converts to sex hormones, it can affect hormone-sensitive conditions and is contraindicated in individuals with hormone-sensitive cancers. Supplementation requires monitoring of DHEA-S levels, sex hormones, and other relevant health markers. Your doctor will determine whether DHEA is appropriate based on your individual health profile.
Prebiotics and probiotics are complementary approaches to supporting the gut microbiome — the complex ecosystem of trillions of microorganisms that inhabit the digestive tract and influence far more than digestion alone. Probiotics introduce beneficial bacteria and yeasts directly into the gut. Prebiotics are specialised plant fibres that serve as fuel for those beneficial organisms. Together, they promote a balanced, diverse microbiome which plays a critical role in immune function, mental health, metabolism, and overall wellbeing.
These non-digestible fibres pass through the upper digestive tract and ferment in the colon, selectively nourishing beneficial bacteria. This fermentation produces short-chain fatty acids (SCFAs) which provide energy for colon cells, reduce inflammation, support the intestinal barrier, and may offer protective effects against colorectal cancer. Prebiotic supplementation can also improve mineral absorption, support regular bowel movements, and contribute to metabolic health through improved glucose regulation and appetite control.
Common strains including Lactobacillus and Bifidobacterium species help restore microbial balance, particularly after disruptions from antibiotics, illness, poor diet, or chronic stress. Benefits include improved digestion, reduced bloating, enhanced immune function, and relief from conditions such as IBS, inflammatory bowel disease, and antibiotic-associated diarrhoea. Emerging research suggests probiotics may also influence the gut-brain axis, with potential implications for mood, anxiety, and cognitive function.
Vitamin B12 is an essential water-soluble vitamin critical for red blood cell formation, DNA synthesis, neurological function, and energy metabolism. While B12 is naturally found in animal products, deficiency is commonly caused by poor absorption, dietary restrictions, certain medications, or age-related decline in stomach acid production. B12 injections bypass the digestive system entirely, making them particularly effective for individuals with absorption issues or severe deficiency.
B12 deficiency presents as fatigue, weakness, cognitive fog, memory problems, mood changes, numbness or tingling in extremities, and in severe cases, megaloblastic anaemia and neurological damage. Injectable B12 restores levels rapidly, with many patients reporting noticeable improvements in energy, mental clarity, and overall vitality within days to weeks.
B12 injections are especially relevant for individuals with pernicious anaemia, those who have undergone gastric surgery, people with Crohn's disease or coeliac disease, strict vegans and vegetarians, older adults with reduced gastric acid production, and patients taking metformin or proton pump inhibitors.
Adequate B12 is essential for maintaining the myelin sheath that protects nerve fibres, making it critical for preventing, and potentially reversing, neurological symptoms associated with deficiency. B12 also plays a supporting role in cardiovascular health through its involvement in homocysteine metabolism.
Trueform connects patients with HPCSA licensed healthcare providers who evaluate each patient and may prescribe treatment when clinically appropriate. Following an online consultation, prescriptions are filled by a retail pharmacy fully licensed by the South African Pharmacy Council (SAPC) and certified by the Department of Health (DOH). Providers may prescribe bespoke, compounded medications in certain cases to address patient-specific needs or when commercially available medications are not appropriate or available. These medications are legally manufactured in South Africa in facilities that are inspected by the SAPC and licensed by the DOH and SAPC. While the individual ingredients are clinically studied, compounded formulations are not subject to the same regulatory review as mass-produced, brand-name medications. Although regular third-party lab testing is conducted, compounded medications are not approved or evaluated for safety, effectiveness, or quality by SAHPRA. Results vary based on your unique biology and adherence to your treatment plan.
Book a free introductory call with one of our care coordinators to discuss your goals.
